The Complete Guide to Co-occurring Disorders: Mental Health and Substance Use Treatment

Reviewed by:
Brittany Mausolf, MA, LPCC, LADC


A co-occurring disorder is when a person experiences one or more mental health conditions and a substance use disorder. The conditions may develop at the same time or one may emerge before the other, but they affect each other in ways that can make recovery more difficult without specialized care. 

Common examples include:

  • Depression and alcohol use disorder
  • Anxiety and prescription drug misuse
  • Post-traumatic stress disorder (PTSD) and opioid use disorder
  • Bipolar disorder and stimulant use disorder
  • Attention-deficit/hyperactivity disorder (ADHD) and cannabis use disorder

When these conditions occur together, treatment that addresses both conditions simultaneously, often called integrated treatment, is considered the gold standard of care. Research consistently shows better outcomes when mental health and substance use disorders are treated together rather than separately. 

Definitions

Co-occurring disorders:

The presence of one or more mental health disorders and a substance use disorder in the same person.

Dual diagnosis:

An older term commonly used to describe co-occurring disorders.

Integrated treatment:

An approach that addresses both conditions together through one coordinated care plan.


Why Co-occurring Disorders Matter

Portrait of pensive man looking through window.

When someone is struggling with depression, anxiety, trauma, bipolar disorder or another mental health condition, alcohol or drugs can sometimes seem to offer temporary relief from common symptoms. Unfortunately, the same substances that may initially seem to ease the pain of those symptoms can actually intensify them, complicating diagnosis and making treatment more challenging.

The interaction of substances and mental health disorders can create a negative cycle:

  1. Mental health symptoms increase distress.
  2. Alcohol or drugs are used to cope.
  3. Substance use worsens emotional or psychiatric symptoms.
  4. Functioning declines.
  5. More substance use follows.
     

Over time, each condition can reinforce the other. What may have started as occasional drinking to manage anxiety or difficulty sleeping can gradually become an alcohol use disorder. Similarly, ongoing substance use can trigger or worsen depression, anxiety, psychosis and other mental health symptoms. 

For families, the situation often feels confusing because symptoms overlap. Is someone withdrawing from loved ones because they're depressed? Is alcohol contributing to mood changes? Is cannabis increasing anxiety? The answer may be all of the above.

Understanding the connection between these conditions is often the first step toward getting appropriate help.


How Common Are Co-occurring Disorders? 

Co-occurring disorders are more common than many people realize. According to the 2021 National Survey on Drug Use and Health (NSDUH), approximately 19.4 million US adults experienced both a mental health condition and a substance use disorder within the past year. The survey also found that about 44 percent of people with a substance use disorder had a co-occurring mental health condition. 

These numbers are reflected in the experiences of people who seek treatment. The Hazelden Betty Ford Foundation's Butler Center for Research reported that 72 percent of patients treated across Hazelden Betty Ford programs had two or more substance use disorder diagnoses, co-occurring mental health diagnoses or both in its 2026 Patient Outcomes Study Results. Anxiety disorders and depressive disorders were among the most common mental health conditions identified. 

While the statistics are significant, they also highlight an important point: Experiencing both a mental health condition and a substance use disorder is not unusual. Treatment providers regularly work with individuals facing these overlapping challenges, and effective approaches have been developed to address both conditions together. Understanding how common co-occurring disorders are can help individuals and families recognize that specialized, integrated care is available and designed for situations exactly like these.

Shot of a businesswoman listening intently during a conference


How Mental Health Disorders and Substance Use Disorders Interact

Why do co-occurring disorders happen? 

There is no single cause of co-occurring disorders. Instead, several factors can increase the likelihood that mental health and substance use disorders develop together. At times, it can even be confusing to determine which disorder happened first—or if they happened simultaneously. 

Because these conditions can influence each other in complex ways, effective care starts with understanding the whole person, not just individual symptoms. 


What Is the Difference Between Co-occurring Disorders and Dual Diagnosis? 

Shot of a senior man using a laptop at home

If you've started researching mental health conditions and substance use concerns, you've probably come across terms like co-occurring disorders, dual diagnosis and comorbidity. While these terms are closely related, they aren't always used in the same way. Understanding the differences can make it easier to navigate treatment options and find information that's relevant to your situation.

What is a co-occurring disorder?

In behavioral health care, co-occurring disorders usually refers to a mental health disorder and a substance use disorder occurring in the same person at the same time. 

What is dual diagnosis?

Dual diagnosis is an older term that means essentially the same thing.

Some organizations still use it, but many professionals now prefer the term co-occurring disorders because it reflects a broader understanding of how conditions interact. 

What is comorbidity?

Comorbidity is a broader medical term that refers to two or more conditions occurring together.

Examples:

  • Diabetes and heart disease
  • Depression and anxiety
  • PTSD and alcohol use disorder

While all co-occurring disorders are a form of comorbidity, not all comorbidities involve substance use disorders. 


Common Examples of Co-occurring Disorders

Co-occurring disorders can take many different forms because every person's experience is unique. The list below identifies some of the most common combinations of mental health and substance use disorders. There are countless other ways co-occurring disorders can appear.

Mental Health Condition

Common Co-occurring Substance Use Disorder

Depression

Alcohol use disorder

Anxiety disorders

Alcohol or sedative misuse

PTSD

Opioid use disorder or alcohol use disorder

Bipolar disorder

Alcohol or stimulant use disorder

ADHD

Cannabis or stimulant misuse

Schizophrenia

Nicotine dependence, alcohol use disorder or cannabis use disorder


Mental health diagnoses commonly seen alongside substance use disorders include:

  • Depression
  • Anxiety disorders
  • PTSD
  • Bipolar disorder
  • ADHD
  • Personality disorders
  • Obsessive-compulsive disorder (OCD)
  • Schizophrenia spectrum disorders


Signs and Symptoms of Co-occurring Disorders

The signs of a co-occurring disorder aren't always easy to recognize. Mental health conditions and substance use disorders can share similar symptoms, and each can influence how the other appears. What may look like anxiety, depression or the effects of alcohol or drug use could be part of a more complex picture involving both conditions.

 

Mental health
symptoms
 

Depending on the condition, symptoms may include:
  • Persistent sadness
  • Anxiety or panic attacks
  • Mood swings
  • Difficulty concentrating
  • Irritability
  • Sleep disturbances
  • Feelings of hopelessness
  • Social withdrawal
  • Intrusive memories
  • Excessive worry
  • Thoughts of self-harm

Individuals experiencing thoughts of suicide or self-harm should seek immediate support through emergency services or the 988 Suicide & Crisis Lifeline.

 

Substance use
symptoms
 

Common signs include:
  • Using larger amounts than intended
  • Difficulty stopping
  • Cravings
  • Spending significant time obtaining or using substances
  • Continuing use despite consequences
  • Increased tolerance
  • Withdrawal symptoms
  • Neglecting responsibilities
  • Relationship conflicts
  • Failed attempts to cut back

 

Warning signs loved
ones may notice
 

Changes related to co-occurring disorders are not always obvious at first. Family members, partners and close friends may first notice shifts in mood, behavior or daily routines that signal something deeper is going on. While these signs don't necessarily mean someone has a co-occurring disorder, they may indicate it's time to start a conversation or seek professional guidance.

Watch for:

  • Increased secrecy
  • Sudden mood changes
  • Financial problems
  • Isolation
  • Missing work or school
  • Changes in sleep patterns
  • Declining physical health
  • Loss of interest in activities
  • Risky behavior
  • Frequent crises


What Causes Co-occurring Disorders?

Grandmother and grandson contemplating at home

Researchers do not believe co-occurring disorders stem from a single cause. Instead, they tend to develop through a combination of biological, psychological and environmental factors that influence both mental health and substance use risk. 

Genetics

Having a family history of addiction, mental health conditions or both may increase a person's risk of developing co-occurring disorders. Genetics do not determine someone's future, but they can influence vulnerability and resilience.

Trauma and adverse experiences

Trauma is one of the most significant risk factors associated with co-occurring disorders.

Examples include:

  • Childhood neglect or abuse
  • Domestic violence
  • Sexual assault
  • Military combat exposure
  • Serious accidents
  • Loss of a loved one

Some people develop symptoms such as anxiety, depression or PTSD following trauma. Others may turn to alcohol or drugs in an attempt to manage overwhelming emotions, memories or physical symptoms. 

Brain chemistry

Mental health conditions and substance use disorders both affect communication systems within the brain. Changes involving mood regulation, reward pathways, stress responses and impulse control can contribute to the development and progression of co-occurring disorders. 

Environment and stress

Factors such as chronic stress, financial hardship, discrimination, social isolation, housing instability or exposure to substance use can increase the risk of a co-occurring disorder.

While not everyone facing these challenges develops a co-occurring disorder, they can contribute to emotional distress and make healthy coping more difficult.

Family history and learned behaviors

Families influence how people learn to respond to stress, communicate emotions and seek support. Growing up in an environment where substance use is common or mental health concerns go untreated may shape future coping behaviors. Fortunately, family history is only one part of the story. With effective treatment and support, people can develop new skills and healthier ways of managing life's challenges.

While these factors can increase the likelihood of developing co-occurring disorders, they don't determine a person's future. Many people with one or more risk factors never develop a mental health or substance use disorder, while others may experience both. Understanding the potential influences behind co-occurring disorders can help individuals and families make sense of what they're experiencing and find the support that's most likely to help.


How Are Co-occurring Disorders Diagnosed?

Screening and assessment

For many individuals and families, one of the most frustrating aspects of seeking help is trying to understand what's causing the symptoms they're seeing. Mental health concerns and substance use disorders can affect many of the same areas of life, making it difficult to know where one begins and the other ends. 

Getting an assessment is the first step in diagnosis, and it helps determine next steps. A comprehensive assessment typically explores:

  • Current substance use
  • Mental health symptoms
  • Physical health
  • Family history
  • Trauma history
  • Medications
  • Previous treatment experiences
  • Recovery goals
Stethoscope with Clipboard and Laptop on Desk

A thorough assessment helps create a clearer picture of what's happening and what kind of support may be most helpful. This often includes screening and assessment tools, along with conversations about symptoms, health history, substance use, life experiences and personal goals for recovery. It also considers how symptoms interact over time rather than viewing each condition in isolation. 

Why diagnosis can be challenging

Mental health symptoms and substance use symptoms often overlap.

For example:

  • Alcohol use can contribute to depression.
  • Anxiety can increase substance use.
  • Sleep disturbances can occur with both conditions.
  • Both addictive use and withdrawal symptoms may resemble psychiatric symptoms. 

Because of this complexity, clinicians need time to understand what symptoms existed before substance use, what symptoms emerged afterward and how both conditions influence each other. 

Shared decision-making matters

At Hazelden Betty Ford, assessment is not something that's done to a person. It's a collaborative process that combines clinical expertise with an individual's experience, goals and preferences.

This approach, often called shared decision-making, helps people participate actively in treatment planning and recovery decisions. 

Mental health services at Hazelden Betty Ford

Hazelden Betty Ford provides integrated care designed to address substance use disorders and many common co-occurring mental health conditions.

Learn more about Hazelden Betty Ford's mental health services, including treatment for depression, bipolar disorder and other co-occurring mental health conditions. 

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Treatment Options for Co-occurring Disorders

Before diving into specific treatment approaches, it's important to know that help is available. Co-occurring disorders can feel complicated, but effective treatments exist, and millions of people have found recovery from both substance use disorders and mental health conditions. The first step is finding care that recognizes how these challenges interact and addresses them together.

What is integrated treatment?

Integrated treatment is an approach that addresses mental health and substance use disorders at the same time through a coordinated treatment plan.

Instead of treating one condition first and addressing the other later, integrated care recognizes that both conditions influence one another and should be addressed together. Research has shown that integrated treatment generally leads to better outcomes because care is coordinated around the individual's needs. 

Why is integrated treatment considered the gold standard?

A growing body of research supports treating mental health and substance use disorders together rather than separately. Integrated treatment allows providers to address the ways these conditions influence one another, which can improve treatment engagement, reduce symptoms and support long-term recovery. Leading organizations including the National Institute on Drug Abuse (NIDA) recommend coordinated approaches that address both conditions as part of a single treatment plan whenever possible.

Risks of treating conditions separately 

A person might:

  • Visit one provider for addiction treatment
  • See another provider for mental health care
  • Receive different recommendations
  • Be expected to coordinate everything independently

Benefits of treating both conditions together

Integrated care may help:

  • Reduce symptoms more effectively
  • Improve treatment engagement
  • Strengthen recovery skills
  • Improve quality of life
  • Reduce relapse risk
  • Improve communication among providers
  • Support long-term recovery goals

Common components of treatment 

Treatment for co-occurring disorders often includes a range of evidence-based therapies and supportive services tailored to an individual's needs. Along with addressing symptoms, these approaches help individuals build coping, emotional regulation and life skills that support overall functioning and long-term recovery.

Recovery goals look different for everyone. For one person, success may mean reducing anxiety and rebuilding trust with family members. For another, it may involve maintaining sobriety, returning to work, improving physical health or feeling more present and engaged in everyday life. Effective treatment helps people identify what recovery means to them and develop a plan to support those goals. 


What to Expect During Treatment

Taking the first step toward treatment can bring up a range of emotions. Some people feel relieved to finally have answers. Others may feel nervous about what treatment will involve, whether they'll be understood or if recovery is truly possible.

At Hazelden Betty Ford, treatment begins with meeting people where they are. Co-occurring disorders can be complex, but help is available. Our multidisciplinary teams have extensive experience treating both mental health conditions and substance use disorders, and we understand that every person's story, challenges and strengths are different. Treatment is designed to provide a safe, supportive environment where individuals can gain a better understanding of what they're experiencing, develop practical recovery skills and begin building a healthier future. Integrated care, personalized treatment planning and collaboration with patients and families are central to this approach.
 

Before admission

The process often begins with:

  • A confidential conversation
  • Insurance verification
  • Clinical assessment
  • Treatment recommendations

The first week

Early treatment may focus on:

  • Stabilization
  • Orientation
  • Assessment
  • Goal-setting
  • Building trust with the treatment team

Weeks two through four

As treatment progresses, individuals often participate in:

  • Group counseling
  • Individual therapy
  • Mental health services
  • Skill-building to manage symptoms
  • Family programming
  • Recovery education
  • Relapse prevention planning

Discharge planning

Discharge planning begins well before treatment ends.

The goal is to create a realistic plan that supports continued recovery and addresses both mental health and substance use concerns after treatment. 

After treatment

Recovery continues long after a formal treatment program ends.

Continuing care planning may include:

  • Outpatient treatment
  • Therapy
  • Medication management
  • Recovery meetings
  • Alumni support
  • Family services

Find Support for Co-occurring Disorders

When mental health and substance use concerns overlap, comprehensive care can make a meaningful difference. Hazelden Betty Ford's integrated treatment approach is designed to address the whole person, not just individual symptoms. Whether you're looking for answers, exploring treatment options or ready to get help, our team can guide you through the next steps.

Call 1-866-831-5700 to speak with an admissions specialist or click to learn more about available treatment options.

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Can Someone Recover from Co-occurring Disorders?

Yes.

Research shows that people with co-occurring disorders can and do recover, especially when both conditions are treated together through an integrated approach. Research conducted by the Hazelden Betty Ford Foundation's Butler Center for Research has helped expand understanding of the factors that support long-term recovery, including continued engagement in treatment, recovery support and attention to mental health needs alongside substance use recovery. 

What does research show about recovery? 

Evidence from the Hazelden Betty Ford Foundation's Butler Center for Research reinforces what clinicians see every day: Recovery from co-occurring disorders is possible. In the 2026 Patient Outcomes Study Results, the Butler Center found that patients in treatment experienced improvements in multiple measures of mental health, including symptoms of anxiety, depression and PTSD. The report also found that 86 percent of patients rated their overall quality of life as good or better during the year following treatment, and 85 percent reported good or better overall health. 

While recovery looks different for everyone, these findings highlight the important reality that meaningful improvements in mental health, physical health and quality of life are achievable when people receive integrated care and ongoing support. 

ID 336, Where do I begin

What improves long-term outcomes?

Recovery doesn't happen because of a single decision, treatment experience or breakthrough moment. It is often built through a series of small, intentional steps taken over time. While every person's path is different, clinicians and researchers have identified several factors that can strengthen recovery, support ongoing healing and improve long-term outcomes for individuals living with co-occurring disorders:

  • Early intervention
  • Integrated care
  • Ongoing support
  • Family involvement
  • Treatment engagement
  •  A strong recovery network

What about relapse?

When discussing substance use disorders, you may hear the term "relapse." At Hazelden Betty Ford, clinicians often use the phrase return to use because it recognizes that recovery is an ongoing process rather than a pass-or-fail event. Moreover, addiction, along with many mental health conditions, is chronic. It is not uncommon for symptoms to recur and warrant additional or further treatment.

For individuals living with co-occurring disorders, a return to use or a recurrence of mental health symptoms does not mean treatment has failed or that recovery is out of reach. Just as symptoms of depression, anxiety, bipolar disorder or other mental health conditions can recur, some people may experience a return to substance use during the recovery process. What matters most is how those experiences are addressed. 

A return to use is not a sign of failure. Instead, it's a key indicator about what support may be needed next. It may signal the need for additional recovery resources, changes in mental health treatment, stronger coping strategies or renewed engagement with a support network. With the right care and support, many people can learn from setbacks, regain momentum and continue making progress toward their recovery goals.

Relapse prevention and recovery support

Recovery from co-occurring disorders involves more than avoiding alcohol or other drugs. It also involves managing mental health symptoms, building coping skills and developing a support system that can help with navigating life's challenges.

Research and clinical experience consistently show that recovery is strengthened when people have meaningful connections with others who support their goals. Whether that support comes from family members, treatment professionals, peers in recovery, faith communities or mutual-help groups, strong relationships can provide accountability, encouragement and perspective during both difficult and successful periods of recovery.

A recovery support system is the support you receive from those around you that uplifts you, encourages a better version of you, and gives you a sense of belonging and connection.


Hazelden Foundation, Living in Balance: Co-occurring Disorders Sessions, Session 45: Recurrence Prevention

Many people focus on what they need to avoid during recovery. Just as important is identifying what they need to build. A strong recovery support system often includes people who understand the importance of both substance use recovery and mental health management and who can provide encouragement, honest feedback and support during difficult times. 

Examples may include:

  • Family members and trusted friends
  • Therapists and counselors
  • Physicians and mental health providers
  • Peer recovery specialists
  • Twelve Step sponsors
  • Recovery support groups
  • Faith or spiritual communities
  • Others in long-term recovery

For many people, recovery becomes more sustainable when they openly communicate their goals, identify trusted sources of support and develop a plan for responding to triggers, cravings, mental health symptoms or a potential return to use.


Hazelden Foundation, Living in Balance: Co-occurring Disorders Sessions, Session 45: Recurrence Prevention (Hazelden Publishing, 2009, 2015, 2025), 2-16, 22-29.


Guidance for Family Members

Portrait of a happy laid-back couple relaxing together at home

When someone you care about is living with a co-occurring disorder, it can be difficult to know how to help. You may be trying to make sense of changing moods, substance use, strained relationships or behaviors that seem out of character. In many families, there is confusion about whether a particular challenge is related to mental health, substance use or both.

One of the challenges of co-occurring disorders is that mental health symptoms and substance use concerns often influence each other. A loved one may be using alcohol or drugs to cope with depression, anxiety or trauma. Substance use may also worsen existing mental health symptoms, creating a cycle that can feel frustrating and overwhelming for everyone involved. 

While you cannot control another person's choices, your support, understanding and willingness to learn can play an important role in recovery.

Start with compassion and curiosity

Conversations about mental health and substance use are often most effective when they come from a place of concern rather than criticism.

Instead of assuming you know what's happening, try creating space for a conversation:

  • "I've noticed you haven't seemed like yourself lately."
  • "You seem to be carrying a lot right now."
  • "I've been worried about you and wanted to check in."
  • "How can I support you?"

The goal isn't to diagnose, fix or convince. The goal is to listen, learn and keep the lines of communication open.

Learn about both conditions

Families sometimes focus on either the mental health condition or the substance use disorder, but treating one while overlooking the other can create additional challenges.

Learning how co-occurring disorders work can help you:

  • Better understand your loved one's experiences
  • Set realistic expectations
  • Communicate more effectively
  • Identify warning signs early
  • Support treatment and recovery efforts

The more informed you are, the more prepared you'll be to respond with empathy and confidence rather than fear or frustration.

Encourage professional help

Many people with co-occurring disorders benefit from treatment that addresses both conditions together.

If your loved one is open to help, you can assist by:

  • Researching treatment options
  • Offering transportation
  • Helping with insurance questions
  • Participating in family programming
  • Encouraging follow-through with treatment recommendations

Integrated treatment approaches are generally associated with better outcomes because they address both mental health and substance use concerns as part of a coordinated plan. 

Remember, recovery involves the whole family

Co-occurring disorders don't just affect the individual experiencing symptoms. They can impact communication, trust, finances, routines and family relationships.

Many families find that their own healing begins when they seek support, education, skill-building opportunities and connection with others who understand what they're experiencing. Family counseling, support groups and educational programs can help family members better understand recovery while caring for their own well-being. Family involvement is also a key component of many integrated treatment models. 

Take care of yourself, too

Supporting someone with a co-occurring disorder can be emotionally demanding. Taking care of yourself isn't selfish. It's part of being able to provide healthy, sustainable support.

Consider:

  • Maintaining boundaries
  • Staying connected to supportive friends and family
  • Seeking counseling or support groups
  • Prioritizing sleep, exercise and self-care
  • Continuing activities that bring meaning and balance to your life

Caring for yourself and caring for a loved one are not competing priorities. Both matter.

Give time for healing

Families do not cause co-occurring disorders, and they cannot cure them. What families can do is provide encouragement, accountability, understanding and hope. Recovery often happens one conversation, one decision and one step at a time. By learning about co-occurring disorders and engaging in the process, families can become an important source of support while helping create an environment that promotes healing for everyone involved.


Insurance and Cost Considerations

Many health insurance plans provide coverage for mental health and substance use disorder treatment.

Coverage varies depending on:

  • Provider network
  • Level of care
  • Location
  • Specific benefits

Questions to ask include:

  • Is the program in-network?
  • What services are covered?
  • What will out-of-pocket costs be?
  • Is prior authorization required?

Hazelden Betty Ford's admissions team can help individuals and families understand available options and verify benefits.


Frequently Asked Questions About Co-occurring Disorders

What is a co-occurring disorder?

A co-occurring disorder occurs when a person experiences both a mental health disorder and a substance use disorder. In some cases, they may have more than one of each condition. 

Is dual diagnosis the same as a co-occurring disorder?

Yes. Dual diagnosis is an older term commonly used to describe co-occurring disorders. 

What causes co-occurring disorders?

Co-occurring disorders may result from a combination of genetics, trauma, environmental factors, brain chemistry and life experiences. 

How common are co-occurring disorders?

Millions of Americans experience both mental health and substance use disorders, according to the 2021 National Survey on Drug Use and Health from the Substance Abuse and Mental Health Services Administration (SAMHSA). 

What percentage of people with substance use disorders have a co-occurring mental health disorder?

According to SAMHSA, approximately 44 percent of people with a substance use disorder also have a mental health condition. 

What are the most common examples of co-occurring disorders?

Common examples include depression and alcohol use disorder, PTSD and opioid use disorder, anxiety and prescription drug misuse, and bipolar disorder with substance use disorders. 

What is integrated treatment for co-occurring disorders?

Integrated treatment addresses mental health and substance use disorders simultaneously through a coordinated plan of care. 

Should co-occurring disorders be treated at the same time?

Research generally supports treating both conditions together because each condition can affect the other. 

How are co-occurring disorders diagnosed?

Diagnosis typically involves a comprehensive assessment of mental health symptoms, substance use patterns, medical history and treatment needs. 

What does the best treatment for co-occurring disorders involve?

The most effective treatment plans are individualized and often include therapy, recovery support, family involvement, mental health services and substance use treatment. 

How do I find treatment for co-occurring disorders?

Look for programs that provide integrated care and have experience treating both mental health and substance use disorders. Learn more through Hazelden Betty Ford's Co-occurring Disorders Facts for Families


Take the Next Step

Seeking help for co-occurring disorders can feel overwhelming, especially when mental health symptoms and substance use concerns have become intertwined. The good news is that effective treatment exists, and recovery is possible.

If you're concerned about yourself or someone you care about, consider taking one of these steps today: